The Science

Two Patches, 16 Powerful Ingredients

There are a lot of myths and home remedies about how to prevent hangovers. But nothing is better than actual science.

GameChanger® uses the science of vitamins, enzymes, amino acids, plant-based extracts, and mineral nutrition to help you prevent and relieve hangovers.  We use a layered approach to hangover prevention and relief through a combination of the WarmUp® and PostGame® Patches.

Here are the patent-pending ingredients that GameChanger Transdermal Patches are made of:

WarmUp Patch

Glutathione is your body’s master antioxidant and detoxifying agent for your liver. It is critical to aid the breakdown and elimination of alcohol by your body, and also helps with unpleasant alcohol flushing. GameChanger WarmUp transdermal patches are the industry’s first hangover patches to replace glutathione in your body directly, by increasing bioavailability avoiding first pass metabolism without the downsides of oral supplements.

Cysteine is powerful antioxidant found in eggs and your body that breaks down into glutathione and replenishes glutathione levels. The increase in Glutathione keeps breaking down alcohol metabolites that give you hangover symptoms such as headaches and nausea. Cysteine is the standard of care for the treatment of acetaminophen toxicity because of these abilities. *Cysteine is present only in GameChanger WarmUp patch.

Alpha Lipoic Acid (ALA)
ALA, an amino acid, is a potent antioxidant that helps your body’s natural production of glutathione.  ALA is essential in at least five enzyme systems involved in the metabolism of alcohol. ALA counters hangover symptoms by reducing the body’s acetaldehyde toxicity and inflammation.  

Milk Thistle Extract (Silymarin)
Milk Thistle is a prickly flowering plant that has been used for centuries as a hangover remedy for its liver boosting properties.  Milk thistle enhances hepatic glutathione and may contribute to the antioxidant defense of the liver.  Milk thistle does this by inhibiting free radicals produced from metabolism of toxic substances such as alcohol, acetaminophen, and carbon tetrachloride.

A unique non-protein amino acid found in green tea, L-theanine may modulate aspects of brain function in humans including inducing a sense of calm.  It also accelerates the breakdown of alcohol metabolites and blocks free radicals from polluting your body.  L-theanine also counteracts alcohol-induced glutathione depletion and allows your body to produce natural antioxidants.
Taurine is a naturally occurring amino acid that has been called a “wonder molecule”.  Studies show that taurine defends liver cells against free radicals and toxins, helping to reduce the severity of oxidative stress-induced liver injury.  Taurine helps get you hydrated at a cellular level, heals sore muscles, improves concentration, and improves the body’s glucose tolerance to minimize the effects of sugar in alcohol and mixers.
Quercetin, a bioflavonoid, is a powerful antihistamine and anti-inflammatory that neutralizes inflammation associated with the pain from a hangover. It also boosts natural defenses by increasing the level and function of enzymes needed for glutathione synthesis in the body. Finally, it reduces buildup of acetaldehyde by improving alcohol metabolism. It gives the GameChanger WarmUp patch its unique yellow hue.
Sweet Lime and Korean Pear Extracts 
Sweet Lime and Korean Pear Extract are fruit extracts that enhance the activity of ADH and ALDH enzymes responsible for breaking down alcohol and faster elimination of acetaldehyde. 
Prickly Pear Extract
Prickly pear is a species of cactus which has potent antioxidant and anti-inflammatory properties due to high levels of polyphenols. Researchers have found that Prickly Pear has a moderate effect on reducing hangover symptoms, by inhibiting inflammation.

PostGame Patch

Hemp Extract (0% THC)         
GameChanger PostGame patch includes natural hemp extract for its abilities to induce calm, mitigate nausea, reduce systemic inflammation and headaches. More importantly, hemp extract assists with restful sleep. Poor or lack of sleep is a main contributor to hangovers in the morning; therefore, GameChanger PostGame patch has been formulated to prioritize recovery during sleep.

Melatonin, a naturally occurring hormone in our body, has become nearly ubiquitous as a sleep aid for millions of people.GameChanger PostGame patch uses the power of melatonin to induce and continue sleep, to overcome depleted glutamate stores in the liver which are responsible for disrupted sleep patterns leading people to wake up periodically throughout the night.

Dihydromyricetin (DHM)
Dihydromyricetin or DHM is a flavonoid extracted from the Japanese raisin tree and has been used for centuries in traditional Asian medicine as a treatment for hangovers and liver disease. DHM increases the rate of alcohol metabolism, improves the ability of your liver enzymes to break down alcohol, to reduce the amount of liver damage caused by alcohol. It can also reduce the desire for more alcohol and counteract alcohol intoxication. GameChanger PostGame patch can help you avoid waking up feeling intoxicated.

B Vitamin Complex (B1, B2, Niacin, B6, Folate and B12)
Alcohol depletes vitamin and mineral stores, and especially your B vitamins.B group vitamins are essential for the proper metabolism of alcohol and efficient breakdown of NAC into glutathione.While you sleep, Gamechanger PostGame patch restores these lost vitamins to help remove the byproducts of alcohol metabolization, helping avoid hangover symptoms without that vitamin smell or taste present in other patches.

Ginger Root Extract
Ginger is a perennial herb known as a natural remedy for motion sickness, nausea, vomiting, and other stomach ailments.

Vitamin C
Vitamin C is an essential cofactor in the enzymatic reactions (ADH and ALDH) that break down alcohol byproducts. It is essential for the proper breakdown of Cysteine into glutathione and also improves the effectiveness of B-complex vitamins by controlling the accumulation of the toxic alcohol metabolites.

Magnesium Malate
Magnesium is an anti-stress mineral that regulates over 800 enzyme actions in the body which are depleted while drinking alcohol. Magnesium helps with hangovers by preventing the thickening of the blood, resulting in tension headaches and pain, while also relaxing head and neck muscle tension that makes hangovers worse.

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FDA. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT DISEASE. The efficacy has not been confirmed by FDA-approved research. Consult your physician before using any product. Drink Responsibly.  It does not make you sober or reduce the impact of drinking alcohol.